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ACP1. Evaluation of Cardiovascular Activity of an Ayurvedic Preparation ‘Kanakasav’in Rat Model

2Danis Rahman, Mohammad Shah Amran1, Nayma Abedin2, M. S. K. Choudhuri2, Md. Abdur Rashid1

1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh. 2Department of Pharmacy, Faculty of Biological Sciences, Jahangirnagar University, Savar, Dhaka, Bangladesh.

1. Abstract: Kanakasav is Ayurvedic medicine used for asthma and chronic bronchitis. Ayurvedic drugs are getting importance and reputation day by day because it has fewer side effects and give necessary pharmacological action. But prolonged and excess usage may lead to harmful effects such as damage of the heart muscle leading to various types of arrhythmia and coronary artery diseases. We have measured the electrocardiographically (ECG) parameters using an ECG machine (Vet 300, EDAN, China) in rat model before and after administration of the drug to assess the cardiovascular profile of Ashokarista. We observed that Ashokarista in a dose-dependent manner (200µg/Kg-3200µg/Kg) produced heart blocks and various types of arrhythmias in rats. We thus conclude that Kanakasav should be used with proper monitoring by the pre-existing heart patients.

Keyword: Ayurvedic, Kanakasav, ECG, Cardiovascular disease, Ketamine.

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